Experts have been debating if Zoloft, also known as sertraline, and alcohol and if they can be mixed. Studies have shown that certain foods can actually help the body absorb Zoloft, however, the manufacturers of Zoloft do not recommend drinking alcohol while on the medication.
The way that Zoloft works is that is affects the serotonin levels of the brain, alcohol also affects the serotonin levels so combining the two may have mixed results. The effects of alcohol has been known to be strengthened by combining it with Zoloft so you can feel drunker faster on the combination. For example, the taking of one drink can cause you to feel as though you are taking two drinks. Combining Zoloft and alcohol can potentially cause slow reflexes, cloudy judgment, fatigue or drowsiness and these symptoms can come on suddenly, without any warning. There is even a possibility that you can feel even more depressed after drinking alcohol than normal.
Some Zoloft users have an unmistakable craving for more alcohol. Zoloft appears to reduce the self-imposed barriers to drinking alcohol so they can become addicted to alcohol. Studies show that Zoloft has been known to cause alcoholism due to the increased craving for alcohol. Those who have been attempting to recover from alcohol addiction are the most prone to developing alcohol cravings but it can happen to anyone who drinks alcohol. {It is believed that taking Zoloft affects the insula of the brain, which is a part of the limbic system that controls addictions and addictive behavior.
It is also known that those who are depressed should not be drinking large amounts of alcohol in the first place as it can add to their depression which would counteract the use of antidepressants. Remember that alcohol is a central nervous system depressant that can make you feel depressed even without Zoloft.
The combining of Zoloft and alcohol can be potentially dangerous. The results of several studies show that taking Zoloft can potentially increase the risk of suicide, and as with all antidepressants, there are strong withdrawal symptoms involved. Consult with a doctor as soon as possible if you are currently combing Zoloft use with alcohol consumption.
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- Problems Encountered with Using Zoloft (zoloftlawsuit.blog.com)

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